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The pre-metastatic niche in lymph nodes: formation and characteristics. | LitMetric

The pre-metastatic niche in lymph nodes: formation and characteristics.

Cell Mol Life Sci

Laboratory of Tumor and Development Biology, GIGA-Cancer, Liege University, Avenue Hippocrate 13, 4000, Liege, Belgium.

Published: August 2021

AI Article Synopsis

  • * Primary tumors prepare sentinel lymph nodes for metastasis by secreting factors or releasing extracellular vesicles, creating a "pre-metastatic niche" that supports the growth of metastatic cells.
  • * The review discusses the structure and composition of lymph nodes, processes involved in pre-metastatic niche formation, and potential future research directions and clinical implications.

Article Abstract

Lymph node metastasis is a crucial prognostic parameter in many different types of cancers and a gateway for further dissemination to distant organs. Prior to metastatic dissemination, the primary tumor prepares for the remodeling of the draining (sentinel) lymph node by secreting soluble factors or releasing extracellular vesicles that are transported by lymphatic vessels. These important changes occur before the appearance of the first metastatic cell and create what is known as a pre-metastatic niche giving rise to the subsequent survival and growth of metastatic cells. In this review, the lymph node structure, matrix composition and the emerging heterogeneity of cells forming it are described. Current knowledge of the major cellular and molecular processes associated with nodal pre-metastatic niche formation, including lymphangiogenesis, extracellular matrix remodeling, and immunosuppressive cell enlisting in lymph nodes are additionally summarized. Finally, future directions that research could possibly take and the clinical impact are discussed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316194PMC
http://dx.doi.org/10.1007/s00018-021-03873-zDOI Listing

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