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Fine tuning of the transcription juggernaut: A sweet and sour saga of acetylation and ubiquitination.
Biochim Biophys Acta Gene Regul Mech
September 2023
Laboratory of Transcription Biology Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 32, India. Electronic address:
Among post-translational modifications of proteins, acetylation, phosphorylation, and ubiquitination are most extensively studied over the last several decades. Owing to their different target residues for modifications, cross-talk between phosphorylation with that of acetylation and ubiquitination is relatively less pronounced. However, since canonical acetylation and ubiquitination happen only on the lysine residues, an overlap of the same lysine residue being targeted for both acetylation and ubiquitination happens quite frequently and thus plays key roles in overall functional regulation predominantly through modulation of protein stability.
View Article and Find Full Text PDF3'-end mRNA processing within apicomplexan parasites, a patchwork of classic, and unexpected players.
Wiley Interdiscip Rev RNA
November 2023
Team Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France.
The 3'-end processing of mRNA is a co-transcriptional process that leads to the formation of a poly-adenosine tail on the mRNA and directly controls termination of the RNA polymerase II juggernaut. This process involves a megadalton complex composed of cleavage and polyadenylation specificity factors (CPSFs) that are able to recognize cis-sequence elements on nascent mRNA to then carry out cleavage and polyadenylation reactions. Recent structural and biochemical studies have defined the roles played by different subunits of the complex and provided a comprehensive mechanistic understanding of this machinery in yeast or metazoans.
View Article and Find Full Text PDFThe Shifting Cultivation Juggernaut: An Attribution Problem.
Glob Chall
August 2022
Department of Plant Biology and Biodiversity Management Addis Ababa 3434 Ethiopia.
Shifting cultivation entails clearing a delimited land and transforming it into arable land. Owing to its complexity, this system has been a subject of debate and intervention since the colonial-era, and is often considered as the "tropical deforestation culprit." Shifting cultivators are often labeled as "forest eaters" and are considered backward and primitive.
View Article and Find Full Text PDFDecolonizing Knowledge Upstream: New Ways to Deconstruct and Fight Disinformation in an Era of COVID-19, Extreme Digital Transformation, and Climate Emergency.
OMICS
May 2022
Centre for Urban and Regional Studies, Discipline of Geography and Environmental Studies, School of Environmental and Life Sciences, Faculty of Science, University of Newcastle, Callaghan, New South Wales, Australia.
Lies and disinformation have always existed throughout human history. However, disinformation has become a "pandemic within a pandemic" with convergence of COVID-19 and digital transformation of health care, climate emergency, and pervasive human-computer interaction in all facets of life. We are living through an era of post-truth.
View Article and Find Full Text PDFJuggernaut Review of 'A dominant character. The radical science and restless politics of J. B. S. Haldane'.
J Genet
January 2021
Centre for Human Genetics, Electronic City, Bengaluru 560 100, India.
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