Postmastectomy radiotherapy (PMRT) is accepted as the standard of care for women with early breast cancer with 4 or more involved axillary nodes. However the role of PMRT in women with 1-3 involved nodes remains controversial and guidelines vary. We present the arguments against advocating postmastectomy radiotherapy for all women with node positive breast cancer.
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http://dx.doi.org/10.1016/j.ejso.2021.06.025 | DOI Listing |
JAMA Netw Open
February 2025
Division of Breast Surgery, Department of Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia.
Importance: Inflammatory breast cancer (IBC) is an aggressive variant for which trimodality treatment (ie, neoadjuvant systemic therapy [NST] followed by modified radical mastectomy without immediate reconstruction and postmastectomy radiotherapy [PMRT]) represents guideline-concordant care (GCC) and is associated with improved overall survival (OS). However, it is unclear whether there are disparities in trimodality treatment receipt among patients with IBC and how such disparities might affect OS.
Objective: To assess trends in IBC trimodality treatment receipt in a contemporary cohort.
Ann Plast Surg
March 2025
Rehabilitation and Technical Aids Center, Taipei Veterans General Hospital, Taipei, Taiwan.
Background: Improving the quality of life increases patients' expectations of postmastectomy breast reconstruction. Increased incidence of breast implant-associated anaplastic large cell lymphoma encourages patients to choose autologous breast reconstruction over implantation. This study aimed to analyze the aesthetic outcomes of autologous breast reconstruction and define factors associated with the results.
View Article and Find Full Text PDFBreast
February 2025
Department of Breast Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Background: The trend towards breast reconstruction post-mastectomy has increased, aiming to enhance patient outcomes and quality of life. This study examines the impact of immediate breast reconstruction (IBR) on survival outcomes compared to mastectomy alone (MA).
Materials And Methods: We conducted a retrospective cohort study of breast cancer patients aged 20-79 years with MA or IBR from 2010 to 2015.
Med Pharm Rep
January 2025
Plastic Surgery Department, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Background: Breast cancer treatment often involves mastectomy and adjuvant therapies such as radiotherapy, which can lead to complications in reconstructive procedures. Tissue expanders are commonly used for immediate breast reconstruction post-mastectomy, but radiation therapy increases the risk of complications like expander extrusion. Lipofilling has emerged as a promising technique to address tissue damage and improve reconstructive outcomes.
View Article and Find Full Text PDFJAMA Netw Open
February 2025
Department of Surgery, Duke University Medical Center, Durham, North Carolina.
Importance: Current practices in axillary treatment for patients with breast cancer who receive a mastectomy for node-positive disease are unknown. For patients who receive postmastectomy radiotherapy (PMRT), the addition of axillary lymph node dissection (ALND) may result in significant overtreatment.
Objectives: To evaluate trends in axillary treatment for patients with limited nodal metastases who receive a mastectomy and identify factors that can be targeted to reduce axillary overtreatment.
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