Worldwide survey of pesticide residues in citrus-flavored soft drinks.

After more than ten years since pesticide residues were detected in citrus-flavored soft drinks, this study reveals that the situation has not changed. A new sensitive multiresidue UHPLC-MS/MS method has been validated for 88 pesticides, which was used to analyze 200 samples manufactured in 67 countries, 80% corresponding to fruit-based soft drinks. The results show that 98% of the samples collected worldwide contained at least one pesticide, and 85% of them contained more than 4 pesticides. 40 out of 88 target compounds were quantified among the screened samples. Europe was the world region with the highest total amount of pesticides, probably due to the higher content of juice concentrate in samples, which may be the main source of the pesticide residues. Nevertheless, residues were also found in samples with no juice, so water quality also plays an important role as the main ingredient of citrus-flavored soft drinks.