Urbanization can lead to changes in urban morphology that alter the urban thermal environment and energy demand. Improving urban ventilation can alleviate the urban heat island effect and reduce urban energy demand. We categorized the ventilation conditions of 31 major cities in China into four levels based on the frontal area index and presented the natural ventilation effects for cities in five different climate zones. We found that the land surface temperature varies between 0.029 and 5.357 °C in areas under the same climate background. Improving ventilation can directly or indirectly contribute to reductions in urban energy consumption. The energy demand in well-ventilated areas can be reduced by up to 6.704%. The largest reduction in urban energy demand was achieved by improving ventilation within the temperate continental climate zone.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148791 | DOI Listing |
Discov Nano
January 2025
Institute of Physiology II, University of Münster, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Metastatic cancer cells undergo metabolic reprogramming, which involves changes in the metabolic fluxes, including endocytosis, nucleocytoplasmic transport, and mitochondrial metabolism, to satisfy their massive demands for energy, cell division, and proliferation compared to normal cells. We have previously demonstrated the ability of two different types of compounds to interfere with linchpins of metabolic reprogramming, Pitstop-2 and 1,6-hexanediol (1,6-HD). 1,6-HD disrupts glycolysis enzymes and mitochondrial function, enhancing reactive oxygen species production and reducing cellular ATP levels, while Pitstop-2 impedes clathrin-mediated endocytosis and small GTPases activity.
View Article and Find Full Text PDFAntiinflamm Antiallergy Agents Med Chem
January 2025
Institute for Combinatorial Advanced Research and Education, General Sir John Kotelawala Defence University, Ratmalana, Sri Lanka.
The potential of underutilized plant species to improve food security, health, eco-nomic output, and the environment has not been fully realized. Sri Lanka an island on the Indian Ocean is home to numerous plant species with significant medicinal potential, in-cluding many underutilized plants that could help meet the growing demand for food, en-ergy, medicines, and industrial resources. Globally, there are over a thousand known and unknown phytochemicals derived from plants.
View Article and Find Full Text PDFArch Insect Biochem Physiol
January 2025
College of Agriculture, Ibaraki University, Inashiki, Japan.
Aphids exhibit a unique reproductive strategy known as pseudoplacental viviparity, in which embryos develop internally and are thought to receive nutrients such as sugars and amino acids directly from the maternal hemolymph through an ovariole sheath, bypassing the need for traditional yolk storage. This system enables viviparous aphids to adapt to diverse and potentially stressful environments by transmitting maternal environmental cues that influence transgenerational plasticity. However, the mechanisms underlying this nutrient-mediated plasticity are poorly understood.
View Article and Find Full Text PDFFront Cell Neurosci
January 2025
IDDRC, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California - Los Angeles, Los Angeles, CA, United States.
Once believed to be the culprits of epileptogenic activity, the functional properties of balloon/giant cells (BC/GC), commonly found in some malformations of cortical development including focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC), are beginning to be unraveled. These abnormal cells emerge during early brain development as a result of a hyperactive mTOR pathway and may express both neuronal and glial markers. A paradigm shift occurred when our group demonstrated that BC/GC in pediatric cases of FCDIIb and TSC are unable to generate action potentials and lack synaptic inputs.
View Article and Find Full Text PDFBackground Lactate, once considered merely a byproduct of anaerobic metabolism, is now recognized as a crucial neuromodulator in the brain, particularly during high-energy demands. Recent studies have explored its role in neuroprotection, cognitive enhancement, and neural plasticity. This study investigates the effects of elevated blood lactate levels, induced by acute exercise, on visual evoked potentials (VEPs), which reflect neural activity in the visual cortex.
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