A new pair of cytotoxic enantiomeric isoprenylated chromone derivatives from sp.

A new pair of enantiomeric isoprenylated chromone derivatives, (±)-pestaloficiol X [(±)-], along with a known compound pestaloficiol J (), were isolated from the plant endophytic fungus sp. The racemic mixture was separated through chiral HPLC. The structures of new compounds (±)- were elucidated on the basis of extensive spectroscopic data and their absolute configurations were further configured through computational analysis of their electronic circular dichroism (ECD) spectra. Compound (+)- showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC values of 1.35 ± 0.15 and 3.70 ± 0.33 μM, respectively, while compound (-)- showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC values of 2.39 ± 0.26 and 2.99 ± 0.35 μM, respectively.