AI Article Synopsis
- In the mid-20th century, researchers discovered that adult mammals can generate new neurons (adult neurogenesis) and identified the significance of rapid eye movement (REM) sleep for brain function and memory.
- This newfound understanding of neuron regeneration encouraged scientists to think about repairing brain damage, while the insights into sleep suggested important roles in memory processes.
- Advanced techniques like calcium imaging and optogenetics have recently allowed scientists to observe and control specific neurons in real time, revealing that newly formed neurons are crucial for consolidating memories during sleep in mice.
Article Abstract
In the middle of the 20 century, adult neurogenesis and rapid eye movement sleep were discovered independently in mammals. The former prompted the idea to apply this rare cellular regenerative capacity in the adult central nervous system to restore damaged brain circuitry, and the latter led to the finding of dynamic brain state changes during sleep and their functional ramifications, including those for memory consolidation. Recently, calcium imaging analysis and optogenetic manipulation have enabled the examination of the activity of specific neuronal populations with precise timing. These technological advances, which allow for the investigation of adult-born neuron activity during sleep in mice, led us to discover its essential function for memory consolidation.
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| http://dx.doi.org/10.11477/mf.1416201841 | DOI Listing |
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