Pediatrics
Department of Pediatrics.
Published: August 2021
Synthetic cannabinoids are a heterogenous group of novel, legally regulated psychoactive substances that can result in broad, multisystemic, dangerous effects. Despite growing literature regarding synthetic cannabinoid toxicity, little is known about the extent of these effects in young children. Caregivers of drug-endangered children may not provide an accurate history of exposure when children present with symptoms of intoxication, and lack of swift detection on routine urine drug screens may further obscure and delay the diagnosis. Clinical recognition carries forensic relevance that may support interventions to aid in protecting vulnerable children. We describe a case of near-fatal child maltreatment due to supervisory neglect resulting from ingestion of an increasingly common synthetic cannabinoid. Furthermore, we highlight clinical findings that should increase a physician's index of suspicion for synthetic cannabinoid toxicity, even in the absence of a history of exposure.
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http://dx.doi.org/10.1542/peds.2021-050888 | DOI Listing |
Drug Test Anal
March 2025
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Since 2021, products claiming to contain Δ-tetrahydrocannabinol (Δ-THC) analogs have been distributed online and in physical stores, including liquid cartridges for electronic cigarettes, herbal products, and gummy products. This study identified the ingredients in products claiming to contain THC analogs distributed online. Seven oil products and one herbal product were analyzed via gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-photodiode array-mass spectrometry (LC-PDA-MS).
View Article and Find Full Text PDFJ Appl Toxicol
March 2025
Department of Molecular Biology and Genetics, Science Faculty, Atatürk University, Erzurum, Türkiye.
Detailed studies on the embryotoxic and teratogenic effects of synthetic cannabinoids known to be abused are very limited. The present study aimed to evalutate the possible embryotoxic, teratogenic, behavioral, and molecular effects of 4F-MDMB-BUTICA, a new generation synthetic cannabinoid, using zebrafish embryos. The zebrafish embryos were exposed to the cannabinoid at 0.
View Article and Find Full Text PDFBackground: Male factor infertility (MFI) is responsible for 50% of infertility cases and in 15% of the cases sperm is absent due to germ cell aplasia. Human induced pluripotent stem cell (hiPSC)-derived spermatogonial stem cells (hSSCs) could serve as an autologous germ cell source for MFI in patients with an insufficient sperm yield for assisted reproductive technology (ART). The endocannabinoid system (ECS) has been implicated to play a role in mouse embryonic stem cells (mESCs) and the human testicular environment.
View Article and Find Full Text PDFPharmacol Res
March 2025
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, 47405 United States; Program in Neuroscience, Indiana University Bloomington, Bloomington, IN, 47405 United States; Gill Institute for Neuroscience, Indiana University, Bloomington, IN, 47405 United States. Electronic address:
Recreational use of synthetic cannabinoid agonists (i.e., "spice compounds") that target the cannabinoid type 1 receptor (CB) can cause acute respiratory failure in humans.
View Article and Find Full Text PDFACS Omega
March 2025
Department of Life Sciences, University of Bath, Bath BA2 7AY, U.K.
Synthetic cannabinoids (SCs) are novel psychoactive substances (NPS) that are highly potent and associated with a range of severe toxicities. SC use, which is common in UK prisons and homeless communities, typically involves combustion of SC-soaked herb or paper material. Recently, e-cigarettes (or vapes) have emerged as popular delivery vehicles for SCs, and consumption among the general population has risen significantly.
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