Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.hbpd.2021.06.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sphk1/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis.
Cell Death Dis
December 2024
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450000, China.
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and limited therapeutic options. The blood-brain barrier (BBB) breakdown post-ICH exacerbates secondary brain injury, highlighting the need for targeted therapies to preserve the BBB integrity. We aim to investigate the role of the Sphk1/S1P pathway in BBB breakdown following ICH and to evaluate the therapeutic potential of Sphk1 inhibition in mitigating this breakdown.
View Article and Find Full Text PDFHydroxysafflor yellow A, a natural food pigment, ameliorates atherosclerosis in ApoE mice by inhibiting the SphK1/S1P/S1PR3 pathway.
Food Sci Nutr
November 2024
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Institute of Chinese Medicine Guangdong Pharmaceutical University Guangzhou Guangdong China.
Atherosclerosis (AS) is the pathologic basis of many cardiovascular diseases (CVDs). Hydroxysafflor yellow A (HSYA) is a valuable natural food pigment that has been reported to have significant health-promoting abilities. However, the anti-AS efficacy and mechanisms of HSYA have not yet been characterized.
View Article and Find Full Text PDFRole of SphK1/S1P/S1PR1 Signaling Pathway in the Progression of Vocal Fold Leukoplakia of Patients With Laryngeal Reflux.
J Voice
November 2024
Department of Otorhinolaryngology, Shanghai Tongren Hospital, Shanghai, China. Electronic address:
Background: Vocal fold leukoplakia (VFL) has a risk of malignant transformation, and the underlying mechanisms remain defined. It was assumed that laryngopharyngeal reflux (LPR) may contribute to the occurrence of VFL. Studies showed that sphingosine kinase 1 (Sphk1) was highly expressed in the gastroesophageal reflux-related gastrointestinal tumors.
View Article and Find Full Text PDFSphingosine kinase 1 is induced by glucocorticoids in adipose derived stem cells and enhances glucocorticoid mediated signaling in adipose expansion.
bioRxiv
September 2024
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.
Sphingosine kinase 1 (SphK1) plays a crucial role in regulating metabolic pathways within adipocytes and is elevated in the adipose tissue of obese mice. While previous studies have reported both pro- and inhibitory effects of SphK1 and its product, sphingosine-1-phosphate (S1P), on adipogenesis, the precise mechanisms remain unclear. This study explores the timing and downstream effects of SphK1/S1P expression and activation during adipogenesis.
View Article and Find Full Text PDFSPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade.
Cell Death Dis
September 2024
Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
SPHK1 (sphingosine kinase type 1) is characterized as a rate-limiting enzyme in sphingolipid metabolism to phosphorylate sphingosine into sphingosine-1-phosphate (S1P) that can bind to S1P receptors (S1PRs) to initiate several signal transductions leading to cell proliferation and survival of normal cell. Many studies have indicated that SPHK1 is involved in several types of cancer development, however, a little is known in bladder cancer. The TCGA database analysis was utilized for analyzing the clinical relevance of SPHK1 in bladder cancer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!