All membrane-bound organelles are degraded during the terminal differentiation of lens fiber cells. How these organelles are degraded has been a long-standing question in biology. We recently revealed that PLAAT (phospholipase A and acyltransferase)-family phospholipases degrade organelles in the lens independently of macroautophagy. Here, we discuss the mechanism and physiological relevance of this new mode of intracellular degradation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496548 | PMC |
| http://dx.doi.org/10.1080/15548627.2021.1950372 | DOI Listing |
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