Objective: Assisted reproductive technology (ART), an effective treatment modality for infertility, is associated with a higher prevalence of congenital anomalies such as congenital heart defects (CHDs). The present study aimed to evaluate data linking CHDs in infants to pregnancies resulting from fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI).

Methods: In this study, we conducted a systematic literature search on CHDs in infants following IVF/ICSI in Google Scholar, Embase, Scopus, MEDLINE, and PubMed databases from inception to February 2020. The search strategy used combinations of search keywords that included assisted reproductive technology/ART, fertilization/IVF, intracytoplasmic sperm injection/ICSI, birth defect, congenital malformation, and congenital heart defects.

Results: Fifty-six studies fulfilled the inclusion criteria and were selected in the current systematic review, which assessed the association between ART and the risk of CHDs.

Conclusion: Children conceived by IVF/ICSI manifested an increased risk of CHDs compared with spontaneously conceived children. Further studies are needed to assess the long-term cardiovascular safety of these techniques, which is important for the counseling of patients before the use of ART.

Download full-text PDF

Source
http://dx.doi.org/10.1080/14767058.2021.1949705DOI Listing

Publication Analysis

Top Keywords

intracytoplasmic sperm
12
congenital heart
12
sperm injection
8
heart defects
8
assisted reproductive
8
chds infants
8
congenital
5
association in vitro
4
in vitro fertilization
4
fertilization intracytoplasmic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!