Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1056/NEJMcpc2004992 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients.
BMC Anesthesiol
January 2025
Department of Anesthesiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 54 Youdian Road, Hangzhou, 310006, China.
Background: Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration of action, and quick and smooth recovery. However, the pharmacokinetic characteristics of continuous infusions and the correlation between the plasma concentration and the bispectral index (BIS) in elderly patients are still unknown.
Method: In this randomized, controlled study, thirty elderly patients (62-78 years old) undergoing elective gastrointestinal tumor resection were treated with propofol (N = 15) or ciprofol (N = 15) as sedatives during anesthesia.
The aim of the study is to apply mathematical methods to generate forecasts of the dynamics of random values of the percentage increase in the total number of infected people and the percentage increase in the total number of recovered and deceased patients. The obtained forecasts are used for retrospective forecasting of COVID-19 epidemic process dynamics in St. Petersburg and in Moscow.
View Article and Find Full Text PDFPragmatic algorithm for visual assessment of 4-Repeat tauopathies in [F]PI-2620 PET Scans.
Neuroimage
February 2025
Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. Electronic address:
Aim: Standardized evaluation of [F]PI-2620 tau-PET scans in 4R-tauopathies represents an unmet need in clinical practice. This study aims to investigate the effectiveness of visual evaluation of [F]PI-2620 images for diagnosing 4R-tauopathies and to develop a straight-forward reading algorithm to improve objectivity and data reproducibility.
Methods: A total of 83 individuals with [F]PI-2620 PET scans were included.
Deciphering the Resistome and Mobiolme of an Avian-Associated ST249 Clone that Acquired Vancomycin Resistance Isolated from Neutropenic Patient in Tunisia.
Microb Drug Resist
December 2024
Laboratory Ward, National Bone Marrow Transplant Center, Tunis, Tunisia.
Article Synopsis
- - The study identified the first vancomycin-resistant Enterococcus (VREfs) strain in Tunisia from an 8-year-old patient with bone marrow issues, using whole-genome sequencing (WGS) after isolating it during a hospital stay.
- - The strain showed significant resistance levels, with minimum inhibitory concentrations of vancomycin >256 mg/L and teicoplanin at 16 mg/L, and was classified as the ST249 clone typically found in avian sources.
- - This report highlights a novel case where an initially vancomycin-susceptible strain acquired resistance via a plasmid that carried a transposon, aided by specific genetic mechanisms related to conjugation and CRISPR interference
Dietary Habits and Determinants of Overnutrition Among Secondary and Preparatory School Adolescents: A Multi-Center Unmatched Case-Control Study.
Am J Lifestyle Med
August 2024
Department of Pediatrics and Child health Nursing, College of Medical and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia (SBA, HMW).
Overnutrition is characterized by abnormal or excessive fat buildup in the body's fatty tissue, leading to potential health issues associated with overweight or obesity. These conditions pose significant public health challenges for adolescents and are strong indicators of future obesity, illness, and even death. As a result, this study sought to examine the dietary behaviors and factors contributing to overnutrition in secondary and preparatory school students in Debre Berhan Town, Ethiopia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!