Mitochondria are viable therapeutic targets for a broad spectrum of ocular diseases.
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| http://dx.doi.org/10.1167/tvst.10.8.4 | DOI Listing |
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mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
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Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
In a phenotypical screen of 56 acute myeloid leukemia (AML) patient samples and using a library of 10,000 compounds, we identified a hit with increased sensitivity toward -mutated and adverse risk AMLs. Through structure-activity relationship studies, this hit was optimized into a potent, specific, and nongenotoxic molecule called UM4118. We demonstrated that UM4118 acts as a copper ionophore that initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis.
View Article and Find Full Text PDFPKM2 interacts with and phosphorylates PHB2 to sustain mitochondrial quality control against septic cerebral-cardiac injury.
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Department of Rehabilitation Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, China.
Sepsis induces profound disruptions in cellular homeostasis, particularly impacting mitochondrial function in cardiovascular and cerebrovascular systems. This study elucidates the regulatory role of the Pyruvate Kinase M2 (PKM2)- Prohibitin 2 (PHB2) axis in mitochondrial quality control during septic challenges and its protective effects against myocardial and cerebral injuries. Employing LPS-induced mouse models, we demonstrate a significant downregulation of PKM2 and PHB2 in both heart and brain tissues post-sepsis, with corresponding impairments in mitochondrial dynamics, including fission, fusion, and mitophagy.
View Article and Find Full Text PDFTissue heterogeneity of mitochondrial activity, biogenesis and mitochondrial protein gene expression in buffalo.
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Laboratory of Mitochondrial Biology of Farm Animals, Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal, Haryana, India.
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Erratum in: The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease.
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The Impact of Fast Radiation on the Phylogeny of Fruit Flies as Revealed by Multiple Evolutionary Models and Mutation Rate-Calibrated Clock.
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Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
Several true fruit flies (Tephritidae) cause major damage to agriculture worldwide. Among them, species of the genus are extensively studied to understand the traits associated with their invasiveness and ecology. Comparative approaches based on a reliable phylogenetic framework are particularly effective, but several nodes of the phylogeny are still controversial, especially concerning the reciprocal affinities of the two major pests and .
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