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Biomarkers.
Alzheimers Dement
December 2024
Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by early changes in brain structure and cognitive function before the age of onset. This study investigated whether the genetic load for clinical AD and AD pathology predicts AD-related brain and cognitive changes over a 3-year period, targeting the preclinical phase in cognitively unimpaired (CU) middle-aged individuals.
Method: The sample of the study was defined by 429 CU middle-aged participants at risk of AD from the ALFA+ nested cohort with available information on genetics, brain imaging markers and cognitive data [Table 1].
Alzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Barcelona?eta Brain Research Center (BBRC), Barcelona, Spain.
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by early changes in brain structure and cognitive function before the age of onset. This study investigated whether the genetic load for clinical AD and AD pathology predicts AD-related brain and cognitive changes over a 3-year period, targeting the preclinical phase in cognitively unimpaired (CU) middle-aged individuals.
Method: The sample of the study was defined by 429 CU middle-aged participants at risk of AD from the ALFA+ nested cohort with available information on genetics, brain imaging markers and cognitive data [Table 1].
Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts.
Cardiovasc Diabetol
January 2025
State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Among hypertensive cohorts across different nations, the relationship between the triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence and mortality remains to be elucidated.
Methods: This study enrolled 9,283, 164,357, and 5,334 hypertensives from the National Health and Nutrition Examination Survey (NHANES), UK Biobank (UKBB), and Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models and Mendelian randomization analysis.
Treatment of a Radiation-Associated Femur Fracture with an Intercalary Endoprosthesis: A Case Report.
JBJS Case Connect
October 2024
Department of Orthopedic Oncology, MD Anderson Cancer Center, Houston, Texas.
Case: A 72-year-old woman with undifferentiated pleomorphic sarcoma of the thigh received neoadjuvant chemotherapy and radiotherapy. She underwent wide resection and was scheduled for prophylactic fixation of the femur. However, prophylactic fixation was deferred secondary to COVID-19 pandemic.
View Article and Find Full Text PDFThe influence of thermal and hypoxia induced habitat compression on walleye (Sander vitreus) movements in a temperate lake.
Mov Ecol
January 2025
Great Lakes Laboratory for Fisheries and Aquatic Science, Fisheries and Oceans Canada, 867 Lakeshore Road, Burlington, ON, Canada.
Background: Globally, temperate lakes are experiencing increases in surface water temperatures, extended periods of summer stratification, and decreases of both surface and deep water dissolved oxygen (DO). The distribution of fish is influenced by a variety of factors, but water temperature and dissolved oxygen are known to be particularly constraining such that with climate change, fish will likely feel the "squeeze" from above and below.
Methods: This study used acoustic telemetry to explore the effects of both thermal stratification and the deoxygenation of the hypolimnion on walleye (Sander vitreus) movements in a coastal embayment in Lake Ontario.
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