Background/aim: Studies have reported that the expression of c-Met and PrP improves tumor progression. However, not much is known about their relationship. We hypothesized that c-Met and PrP interact with each other, and enhance cancer stem cell (CSC) characteristics.
Materials And Methods: Magnetic activated cell sorting was used to examine the interaction between c-Met and PrP The effects of the interaction on downstream signals, stem cell marker expression, and sphere formation of colorectal cancer (CRC) cells were investigated.
Results: We demonstrated the increased expression and binding levels of c-Met and PrP in CRC cells compared to normal colon epithelial cells. We revealed that the c-Met and PrP interaction induced the ERK activation and Oct4 upregulation. The inhibition of c-Met by crizotinib reduced ERK activation and Oct4 expression and suppressed CSC properties.
Conclusion: c-Met and PrP interact with each other, and targeting c-Met using crizotinib could be a powerful strategy for CRC therapy.
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| http://dx.doi.org/10.21873/anticanres.15133 | DOI Listing |
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