Due to unique osteogenic properties, tricalcium phosphate (TCP) has gained relevance in the field of bone repair. The development of novel and rapid sintering routes is of particular interest since TCP undergoes to high-temperature phase transitions and is widely employed in osteoconductive coatings on thermally-sensitive metal substrates. In the present work, TCP bioceramics was innovatively obtained by Ultrafast High-temperature Sintering (UHS). Ca-deficient hydroxyapatite nano-powder produced by mechanochemical synthesis of mussel shell-derived calcium carbonate was used to prepare the green samples by uniaxial pressing. These were introduced within a graphite felt which was rapidly heated by an electrical current flow, reaching heating rates exceeding 1200 °C min. Dense (> 93%) ceramics were manufactured in less than 3 min using currents between 25 and 30 A. Both β and α-TCP were detected in the sintered components with proportions depending on the applied current. Preliminary tests confirmed that the artifacts do not possess cytotoxic effects and possess mechanical properties similar to conventionally sintered materials. The overall results prove the applicability of UHS to bioceramics paving the way to new rapid processing routes for biomedical components.
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http://dx.doi.org/10.1016/j.msec.2021.112246 | DOI Listing |
J Mater Sci Mater Med
January 2025
Department of Neurosurgery, College of Medicine, Soonchunhyang University, Bucheon Hospital, Bucheon, South Korea.
The objective of this study is to fabricate and develop hydroxypropyl methylcellulose (HPMC) hydrogel (HG)-based composite bone cements with incorporation of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and with/without polymethylmethacrylate (PMMA) for vertebroplasty. For animal study, twenty female Wister rats (250-300 g, 12 weeks of age) were divided into four groups including a two non-ovariectomy (NOVX) groups and two ovariectomy (OVX)-induced osteoporosis groups. Two prepared biocomposites including HG/β-TCP/HA and HG/β-TCP/HA/PMMA were injected into the tibial defects of both OVX and NOVX rats for evaluating in vivo osteogenesis after 12 weeks.
View Article and Find Full Text PDFInt J Pharm
January 2025
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address:
In recent years, continuous manufacturing (CM) has become increasingly popular in the pharmaceutical industry for the production of oral solid dosage (OSD) forms. Most of the newly developed active pharmaceutical ingredients (APIs) nowadays are extremely cohesive and sticky with a mean particle size particle of <100μm, a wide particle size distribution (PSD) and a high tendency to agglomerate, making them difficult to accurately dose using loss-in-weight equipment during CM. In this research paper, the effect of various glidants on the volumetric and gravimetric feeding of several APIs was assessed.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Cell Biology, Federal University of Paraná, Post box-19031, Zip code -81531-970, Curitiba, PR, Brazil.
Unlabelled: Bone tissue substitutes are increasing in importance. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) act as a cell matrix and improve its mechanical properties. One of their raw materials is marine-origin by-products.
View Article and Find Full Text PDFSci Rep
January 2025
Advanced Glass and Glass Ceramic Research Laboratory, Department of Physics, University of Lucknow, Lucknow, 226007, India.
Recently, 3-D porous architecture of the composites play a key role in cell proliferation, bone regeneration, and anticancer activities. The osteoinductive and osteoconductive properties of β-TCP allow for the complete repair of numerous bone defects. Herein, β-TCP was synthesized by wet chemical precipitation route, and their 3-D porous composites with HBO and Cu nanoparticles were prepared by the solid-state reaction method with improved mechanical and biological performances.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
Calcified tissues in living organisms, such as bone, dentin, and enamel, often require surgical intervention for treatment. However, advances in regenerative medicine have increased the demand for materials to assist in regenerating these tissues. Among the various forms of calcium phosphate (CaP), tricalcium phosphate (TCP)-particularly its α-TCP form-stands out due to its high solubility and efficient calcium release, making it a promising candidate for bone regeneration applications.
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