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Streptococcus equi-derived extracellular vesicles as a vaccine candidate against Streptococcus equi infection. | LitMetric

Streptococcus equi-derived extracellular vesicles as a vaccine candidate against Streptococcus equi infection.

Vet Microbiol

Research Center for Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Ochang, 28119, Republic of Korea; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, Republic of Korea; Bio-Analytical Science, University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:

Published: August 2021

AI Article Synopsis

Article Abstract

Streptococcus equi subspecies equi is a pathogenic bacterium that causes strangles, a highly contagious respiratory infection in horses and other equines. The limitations of current vaccines against S. equi infection warrants the development of an affordable, safe, and effective vaccine. Because gram-positive extracellular vesicles (EVs) transport various immunogenic antigens, they are attractive vaccine candidates. Here, we purified the EVs of S. equi ATCC 39506 and evaluated them as a vaccine candidate against S. equi infection in mice. As an initial step, comparative proteomic analysis was performed to characterize the functional features of the EVs. Reverse vaccinology and knowledge-based annotations were then used to screen potential vaccine candidates (PVCs) for S. equi ATCC 39506. Finally, 32 PVCs were found to be enriched in the EV fraction, suggesting the usefulness of this fraction as a vaccine. Importantly, a significantly higher survival rate after S. equi infection was detected in mice immunized with S. equi-derived EVs via the intraperitoneal route than in mice immunized with heat-killed bacteria. Of note, immunoprecipitation-mass spectrometry results validated various immunogenic antigens within the EV proteome. In conclusion, our results suggest that S. equi-derived EVs can serve as a vaccine candidate against S. equi infection.

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Source
http://dx.doi.org/10.1016/j.vetmic.2021.109165DOI Listing

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