Background: Contrary to what happens in children and adults, the prevalence and the factors related to hospitalisation for asthma/wheezing in infants with recurrent asthma-like symptoms are poorly known.
Methods: This study is part of the International Study of Wheezing in infants Phase 3; 2,079 infants (aged 12-18 months) with recurrent asthma-like symptoms, from 11 South American centres, were studied to determine the prevalence and the associated factors for wheezing exacerbation admission. Descriptive statistics and multivariate logistic regression were employed for analysis.
Results: The prevalence of admission for wheezing was 29.7% (95% CI 27.7-31.6) and was significantly associated to severe wheezing episodes (OR: 3.89; 95% CI: 2.93-5.18, p < 0.001), physician-diagnosed asthma (OR: 1.79; 95% CI: 1.33-2.41, p < 0.0001), use of inhaled corticosteroids (OR: 1.78; 95%CI: 1.38-2.29, p < 0.0001), maternal tobacco smoking during pregnancy (OR: 1.69; 95% CI: 1.19-2.39, p = 0.003) and onset of wheezing in the first trimester of life (OR: 1.30; 95% CI: 1.02-1.66, p = 0.038). Breast feeding ≥4 months (OR: 0.72; 95% CI: 0.54-0.96, p = 0.004), maternal high educational level (>12 years) (OR: 0.66; 95% CI: 0.51-0.85, p = 0.001) and total monthly household income ≥US$ 3,000 (OR: 0.34; 95% CI: 0.18-0.67, p = 0.002), were protective factors.
Conclusions: Infants with recurrent asthma-like symptoms have a high rate of admissions. Tobacco smoking in pregnancy, viral respiratory illness in the first trimester of life and severe progression were risks for admissions. Improving medical management to prevent severe exacerbations, prolonging the postnatal period at home longer than 3 months, favouring breastfeeding and avoiding smoking during pregnancy may have a preventive role for admissions in infants with recurrent asthma-like symptoms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.15586/aei.v49i4.100 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inflammatory myofibroblastic tumour is a rare tumour. We present an atypical case of Inflammatory myofibroblastic tumour which was trachea in location, histocyte rich and ROS1 rearranged. The patient presented with upper airway obstruction, which was an asthma mimic.
View Article and Find Full Text PDFA longitudinal study of exercise-induced bronchoconstriction and laryngeal obstruction in high school athletes.
Scand J Med Sci Sports
August 2023
Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Background: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are common in elite athletes. Knowledge of which factors are related to incident EIB and EILO is limited. The aim of this study was to explore the course of EIB and EILO in adolescent athletes over a 2 years period and baseline characteristics related to incident EIB.
View Article and Find Full Text PDFWe report a case of a 55-year-old woman who presented to our hospital emergency department with a recurrent right-sided pleural effusion. Her presenting symptom was shortness of breath which first began two years prior after she experienced a blunt thoracic injury. This injury resulted in the rupture of her right silicone breast implant.
View Article and Find Full Text PDFRSV Prevention in All Infants: Which Is the Most Preferable Strategy?
Front Immunol
May 2022
Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe-University Hospital, Frankfurt am Main, Germany.
Article Synopsis
- Respiratory syncytial virus (RSV) poses significant health risks to infants, often leading to hospitalizations and contributing to recurrent wheezing and asthma-like symptoms, making it a global health priority.
- Current preventive measures mainly involve the monoclonal antibody palivizumab, which is only available to a limited group of high-risk infants, leaving the majority unprotected.
- This review explores broader immunization strategies, focusing on maternal immunization and long-acting monoclonal antibodies as viable options to protect all infants during their first RSV season.
Area deprivation and respiratory morbidities in children with bronchopulmonary dysplasia.
Pediatr Pulmonol
September 2022
Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Introduction: Infants and children diagnosed with bronchopulmonary dysplasia (BPD) have a higher likelihood of recurrent hospitalizations and asthma-like symptoms. Socio-environmental factors that influence the frequency and severity of pulmonary symptoms in these children during the preschool age are poorly understood. In this study, we used the Area Deprivation Index (ADI) to evaluate the relationship between the socio-environmental exposures in children with BPD and respiratory outcomes during the first few years of life.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!