Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report.

Objective: To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.

Design: Case report.

Setting: Private in vitro fertilization clinic.

Patients: 25-Year-old woman, G0, with autoimmune POI and PGAS type 2.

Interventions: Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation.

Main Outcomes Measures: Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation.

Results: Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes.

Conclusions: Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.