Background: Carbapenem resistance in Gram-negative bacteria is an ongoing public health problem of global dimensions leaving very few treatment options for infected patients.
Objectives: To study the dissemination of plasmid-borne carbapenemase genes in Gram-negative bacteria from a diagnostic centre in Tamil Nadu, India.
Methods: A total of 151 non-repetitive isolates belonging to 10 genera were collected between January 2015 and December 2016 from a diagnostic centre in Tamil Nadu. The isolates included (57), (45), (10), Typhi (8), (8), (7), (5), (5), (5), (5) and (1).
Results: Of the 151 isolates, 71% (107) and 68% (103) were found to be resistant to meropenem and imipenem, respectively. The most prevalent β-lactamase gene was (22), followed by (21), (11), (9), (8), (7) and (3). We also observed in (4), and three were positive for both, and . Plasmid incompatibility (inc/rep) typing results showed that the resistance genes (11) were present in the isolates carrying plasmid-types IncX, IncA/C, IncFIA-FIB and IncFIIA. The plasmid-borne resistance genes in and were transferred to susceptible AB1157.
Conclusions: This study highlights the prevalence of carbapenem resistance and the acquisition of plasmid-borne carbapenemase genes in Gram-negative bacteria isolated at this centre.
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| http://dx.doi.org/10.1093/jacamr/dlab015 | DOI Listing |
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