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The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening. | LitMetric

AI Article Synopsis

  • The LUCA device is an advanced multi-modal platform that integrates near-infrared time-resolved spectroscopy, diffuse correlation spectroscopy, and clinical ultrasound to enhance thyroid cancer diagnosis.
  • This device aims to improve the specificity and sensitivity of current screening methods for thyroid nodules by simultaneously assessing tissue hemodynamics alongside ultrasound imaging.
  • Testing shows that the LUCA device achieves high-quality measurements with over 97% precision in assessing tissue properties and maintains good reproducibility even with repositioning, making it versatile for various clinical uses.

Article Abstract

We present the LUCA device, a multi-modal platform combining eight-wavelength near infrared time resolved spectroscopy, sixteen-channel diffuse correlation spectroscopy and a clinical ultrasound in a single device. By simultaneously measuring the tissue hemodynamics and performing ultrasound imaging, this platform aims to tackle the low specificity and sensitivity of the current thyroid cancer diagnosis techniques, improving the screening of thyroid nodules. Here, we show a detailed description of the device, components and modules. Furthermore, we show the device tests performed through well established protocols for phantom validation, and the performance assessment for . The characterization tests demonstrate that LUCA device is capable of performing high quality measurements, with a precision in determining tissue optical and dynamic properties of better than 3%, and a reproducibility of better than 10% after ultrasound-guided probe repositioning, even with low photon count-rates, making it suitable for a wide variety of clinical applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221941PMC
http://dx.doi.org/10.1364/BOE.416561DOI Listing

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