AI Article Synopsis
- The study investigates how COVID-19 affected the prognosis of patients with two eye conditions: neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV), focusing on treatment management during the pandemic.
- It includes data from 130 nAMD patients and 76 PCV patients treated between December 2019 and August 2020, analyzing factors like visual acuity and treatment delays.
- Results show that patients who experienced treatment delays suffered worse visual outcomes and a higher rate of complications, highlighting the need for consistent follow-up and timely care during health crises.
Article Abstract
Purpose: To explore the impact of coronavirus disease 2019 (COVID-19) on the prognosis of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV), and share the experience in managing them during pandemics.
Method: This is a retrospective study of nAMD and PCV patients treated at Peking Union Medical College Hospital from 31 December 2019 to 1 August 2020. Baseline demographic and clinical characteristics, best corrected visual acuity (BCVA), optical coherence tomography (OCT) features, duration of delayed treatment and number of anti-vascular endothelial growth factor (VEGF) injections were analyzed.
Results: A total of 130 nAMD patients (155 eyes) and 76 PCV patients (89 eyes) were identified. Compared to the conditions before COVID-19, the BCVA of delayed cases decreased significantly, and the proportion of patients presenting with sub-macular scar was significantly greater in the delayed treatment group ( < 0.05). The BCVA of non-delayed cases remained stable, with the percentage of patients with disease activity sub-retinal fluid and hemorrhage at the fovea decreasing significantly ( < 0.05). The stable cases who did not require anti-VEGF treatment had significantly worse baseline and final BCVA, these patients were likely to be chronic and 'burnt out' cases with significantly worse anatomical structures ( < 0.05).
Conclusions: The delayed cases due to the pandemic suffered compromised visual function and a higher rate of sub-macular scar formation, while the visual function of non-delayed cases remained stable with favorable anatomical outcomes, suggesting the importance of regular follow-up for nAMD and PCV patients. Besides, effective measures of hospitals during pandemics are crucial to provide timely treatment for chronic disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221678 | PMC |
| http://dx.doi.org/10.1177/20406223211026389 | DOI Listing |
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