AI Article Synopsis
- Gastritis is a common gastrointestinal disorder often linked to alcohol consumption, and this study investigates the protective effects of rosmarinic acid (RA) against gastritis in male rats.
- RA was administered in varying doses before inducing gastritis with ethanol, and subsequent evaluations were made on histopathological changes and antioxidant levels in the rats' stomach tissues.
- The results showed that RA significantly reduced gastric ulcers and inflammation, improved mucosal thickness and gastric gland health, while also enhancing antioxidant activity and prostaglandin E2 levels, suggesting its potential as a protective agent against gastritis.
Article Abstract
Background And Purpose: Gastritis is one of the most current gastrointestinal disorders worldwide. Alcohol consumption is one of the major factors, which provides gastritis. Rosmarinic acid (RA) is found in many plants and has powerful antioxidant and anti-inflammatory effects. In this study, the protective effect of RA was evaluated on the histopathological indices, antioxidant ability, and prostaglandin E2 (PGE2) secretion in male rats.
Experimental Approach: Forty-two animals were divided into control, ethanol-induced gastritis, and RA groups, 6 each. The protective groups included RA administration before gastritis induction at 50 mg (R-G50), 100 mg (R-G100), 150 mg (R-G150), and 200 mg (R-G200) doses. Gastritis was induced by gavage of 1 mL pure ethanol in fasted animals. After 1 h of gastritis induction, the rats were sacrificed and stomach tissue was removed.
Findings/results: Histological evaluation revealed that RA significantly attenuated gastric ulcers, leucocyte infiltration, and hyperemia. It also increased mucosal layer thickness and restored gastric glands. Furthermore, RA decreased malondialdehyde level, increased superoxide dismutase, catalase, and glutathione in the stomach tissue, and raised gastric PGE2 level.
Conclusion And Implications: Our study demonstrated that rosmarinic acid has a notable effect on gastritis protection that could be due to increased antioxidant defense and PGE2 secretion, eventually maintenance of mucosal barrier integrity and gastric glands.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216161 | PMC |
| http://dx.doi.org/10.4103/1735-5362.314829 | DOI Listing |
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