Throughout adulthood, individuals follow personal timetables of deadlines that shape the course of aging. We examine 6-year-longitudinal data of perceived personal deadlines for starting with late-life preparation across adulthood. Findings are based on a sample of 518 adults between 18 and 88 years of age. Multilevel regression analyses were conducted to explore changes in personal deadlines for preparation in five domains (i.e., finances, end of life, housing, social connectedness, caregiving) in relation to calendar age, self-rated health, subjective position in life, and sociodemographic variables. Findings suggest that personal deadlines for starting preparatory activities differ depending on calendar age and domain of late-life preparation. Older adults as compared to younger adults are likely to report narrower deadlines for beginning with late-life preparation. Perceived deadlines for late-life preparation were furthermore found to be preponed and slightly dilated over time. Findings suggest that depending on age-graded opportunity structures, individuals flexibly adjust their personal deadlines for late-life preparation.
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http://dx.doi.org/10.1007/s10433-020-00581-8 | DOI Listing |
Alzheimers Dement
November 2024
Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Front Aging Neurosci
April 2024
Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Activin A, a member of the transforming growth factor β (TGF-β) family, is widely recognized for its neurotrophic and neuroprotective function in the developing and injured brain, respectively. Moreover, in the healthy adult brain, activin A has been shown to tune signal processing at excitatory synapses in a fashion that improves cognitive performance. Because its level in human cerebrospinal fluid rises with age, we wondered whether activin A has a role in mitigating the gradual cognitive decline that healthy individuals experience in late-life.
View Article and Find Full Text PDFPsychiatry Res
April 2024
UConn Center on Aging, University of Connecticut, Farmington, CT USA; Department of Psychiatry, UConn School of Medicine, Farmington, CT USA. Electronic address:
J Am Coll Cardiol
February 2024
Brigham and Women's Hospital, Boston, Massachusetts, USA; University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:
Background: Limited data exist regarding risk factors for aortic stenosis (AS). The plasma proteome is a promising phenotype for discovery of novel biomarkers and potentially causative mechanisms.
Objectives: The aim of this study was to discover novel biomarkers with potentially causal associations with AS.
Nat Commun
January 2024
Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Heart failure (HF) causes substantial morbidity and mortality but its pathobiology is incompletely understood. The proteome is a promising intermediate phenotype for discovery of novel mechanisms. We measured 4877 plasma proteins in 13,900 HF-free individuals across three analysis sets with diverse age, geography, and HF ascertainment to identify circulating proteins and protein networks associated with HF development.
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