AI Article Synopsis
- The study analyzed 328 newly diagnosed multiple myeloma patients, focusing on the implications of cytogenetic abnormalities on their prognosis.
- High-risk cytogenetic abnormalities included specific genetic alterations and were categorized into risk groups: standard-risk (no HRCA), intermediate-risk (one HRCA), and high-risk (two or more HRCAs).
- The high-risk group, representing 14.3% of patients, had significantly poorer outcomes in terms of overall and progression-free survival, highlighting the need for more effective treatment options beyond current therapies like bortezomib.
Article Abstract
We retrospectively studied the impact of cytogenetic abnormalities in 328 consecutive newly diagnosed multiple myeloma (MM) patients. High-risk cytogenetic abnormalities (HRCAs) included del (17p), amp/gain (1q21), t(4;14), and t(14;16). We defined a standard-risk group by the absence of HRCA, an intermediate-risk group with one HRCA, and a high-risk (HiR) group with at least two HRCAs. The HiR group constituted 14.3% of patients and was associated with a median overall survival (OS) of 28.6 months and progression-free survival (PFS) of 14.0 months. Moreover, the HiR group predicted poor outcomes for OS and PFS in multivariate analyses, and bortezomib prolongation to nine cycles could not bring additional benefit to this entity, suggesting the necessity of more effective therapies for these patients. Furthermore, we confirmed the independent prognostic impact of amp 1q21 in this real-world study.
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| http://dx.doi.org/10.1080/10428194.2021.1948032 | DOI Listing |
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