AI Article Synopsis
- A new method has been developed for creating chiral organozinc intermediates using iron catalysis and azabicycloalkenes in an enantioselective carbometalation reaction.
- The study shows how chiral phosphine ligands directly coordinate with iron during the reaction process, influencing the formation of bonds.
- This innovative iron-catalyzed reaction is expected to aid in the synthesis of biologically active compounds.
Article Abstract
The first enantioselective carbometalation reaction of azabicycloalkenes has been achieved by iron catalysis to in situ form optically active organozinc intermediates, which are amenable to further synthetic elaborations. The observed chiral induction, along with the DFT and XAS analyses, reveals the direct coordination of the chiral phosphine ligand to the iron centre during the carbon-carbon and carbon-metal bond forming step. This new class of iron-catalysed asymmetric reaction will contribute to the synthesis and production of bioactive molecules.
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Article Synopsis
- A new method has been developed for creating chiral organozinc intermediates using iron catalysis and azabicycloalkenes in an enantioselective carbometalation reaction.
- The study shows how chiral phosphine ligands directly coordinate with iron during the reaction process, influencing the formation of bonds.
- This innovative iron-catalyzed reaction is expected to aid in the synthesis of biologically active compounds.
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