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GWAS and WGCNA uncover hub genes controlling salt tolerance in maize (Zea mays L.) seedlings. | LitMetric

GWAS and WGCNA uncover hub genes controlling salt tolerance in maize (Zea mays L.) seedlings.

Theor Appl Genet

Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region, Maize Research Institute, Sichuan Agricultural University, Chengdu, 611130, China.

Published: October 2021

AI Article Synopsis

  • Two important genes (GRMZM2G075104 and GRMZM2G333183) were found to be key players in helping maize plants tolerate salt stress through genetic studies.
  • Researchers conducted a study involving 305 maize lines, identifying genetic variations linked to salt tolerance, including seven significant single nucleotide polymorphisms and 120 related genes.
  • The analysis revealed that the identified genes not only contribute to salt tolerance but also highlighted specific haplotypes that are favorable for breeding salt-resistant maize varieties.

Article Abstract

Two hub genes GRMZM2G075104 and GRMZM2G333183 involved in salt tolerance were identified by GWAS and WGCNA. Furthermore, they were verified to affect salt tolerance by candidate gene association analysis. Salt stress influences maize growth and development. To decode the genetic basis and hub genes controlling salt tolerance is a meaningful exploration for cultivating salt-tolerant maize varieties. Herein, we used an association panel consisting of 305 lines to identify the genetic loci responsible for Na- and K-related traits in maize seedlings. Under the salt stress, seven significant single nucleotide polymorphisms were identified using a genome-wide association study, and 120 genes were obtained by scanning the linkage disequilibrium regions of these loci. According to the transcriptome data of the above 120 genes under salinity treatment, we conducted a weighted gene co-expression network analysis. Combined the gene annotations, two SNaC/SKC (shoot Na content/shoot K content)-associated genes GRMZM2G075104 and GRMZM2G333183 were finally identified as the hub genes involved in salt tolerance. Subsequently, these two genes were verified to affect salt tolerance of maize seedlings by candidate gene association analysis. Haplotypes TTGTCCG-CT and CTT were determined as favorable/salt-tolerance haplotypes for GRMZM2G075104 and GRMZM2G333183, respectively. These findings provide novel insights into genetic architectures underlying maize salt tolerance and contribute to the cultivation of salt-tolerant varieties in maize.

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Source
http://dx.doi.org/10.1007/s00122-021-03897-wDOI Listing

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