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Trend of sales revenue by year for top selling cancer drugs in the US and the effect of loss of market exclusivity.
J Cancer Policy
December 2024
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Biosimilars and generics have led to reduced cancer drug prices. The effect of biosimilar or generic drug competition on drug manufacturer revenue has not been previously described. In this study, the majority of top selling cancer drugs had a greater than 50 % decline in sales revenue within 2 years of generic or biosimilar market entry, reflecting both the decline in market share and reduction in unit drug price.
View Article and Find Full Text PDFDispensing of zolpidem and benzodiazepines in Brazilian private pharmacies: a retrospective cohort study from 2014 to 2021.
Front Pharmacol
November 2024
Programa de Pós-Graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Objective: The study aimed to evaluate Zolpidem and Benzodiazepines prescription and dispensing data in private pharmacies in Brazil from 2014 to 2021. Methods: This retrospective cohort study was carried out with retrospective open data from the Brazilian Federal Government from January 2014 to August 2021 containing medicines registered in the National Controlled Products Management System (SNGPC).
Results: Between January 2014 and August 2021, a total of 32,441,392 sales of thirteen drugs from the z-drug and benzodiazepine classes used to treat sleep disorders were recorded in Brazil.
The use of wavefront shaping has found extensive application to develop ultra-thin endoscopic techniques based on multimode optical fibers (MMF), leveraging on the ability to control modal interference at the fiber's distal end. Although several techniques have been developed to achieve MMF-based laser-scanning imaging, the use of short laser pulses is still a challenging application. This is due to the intrinsic delay and temporal broadening introduced by the fiber itself, which requires additional compensation optics on the reference beam during the calibration procedure.
View Article and Find Full Text PDFEvaluation of the Peri-Implant Tissues of Patients with Severe Bone Atrophy Treated with a New Short and Extra-Short Implant System-A Pilot Study.
J Funct Biomater
September 2024
Odontology at Ilapeo College, Curitiba 80710-150, Brazil.
This study aimed to assess clinical and radiographic outcomes, including implant survival, marginal bone loss, and patient satisfaction, in individuals with severe bone atrophy treated using a newly developed system of short and extra-short implants. A total of 44 implants (37 short and 7 extra-short) were placed with immediate loading in 11 patients. The patients were followed up at between 6 and 24 months.
View Article and Find Full Text PDFA loop-mediated isothermal amplification test for yaws: a multi-country diagnostic accuracy evaluation.
Lancet Glob Health
November 2024
Faculty of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK; Hospital for Tropical Diseases, London, UK; Division of Infection and Immunity, University College London, London, UK.
Background: To meet the WHO target of eradicating yaws by 2030, highly sensitive and specific diagnostic tools are needed. A multiplex Treponema pallidum-Haemophilus ducreyi loop-mediated isothermal amplification (TPHD-LAMP) test holds promise as a near-patient diagnostic tool for yaws and H ducreyi. We conducted a prospective evaluation in Cameroon, Côte d'Ivoire, Ghana, and the Republic of the Congo to determine the diagnostic accuracy of the TPHD-LAMP test, as well as to assess its acceptability, feasibility, and cost.
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