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Recent advances in rotavirus reverse genetics and its utilization in basic research and vaccine development. | LitMetric

Recent advances in rotavirus reverse genetics and its utilization in basic research and vaccine development.

Arch Virol

Department of Veterinary Science, M. H. Gluck Equine Research Center, University of Kentucky, Lexington, KY, 40546, USA.

Published: September 2021

AI Article Synopsis

  • - Rotaviruses, which are a major cause of diarrheal deaths in young children, have a high rate of gene reassortment and predominantly affect low-income countries, where vaccine efficacy is lower compared to developed nations.
  • - Current vaccines are expensive and raise safety concerns, creating a need for new, more cost-effective vaccines that are safer and more effective against rotavirus.
  • - The introduction of a plasmid-based reverse genetics system (RGS) is a significant advancement that aids in researching viral functions and developing better vaccines for rotavirus.

Article Abstract

Rotaviruses are segmented double-stranded RNA viruses with a high frequency of gene reassortment, and they are a leading cause of global diarrheal deaths in children less than 5 years old. Two-thirds of rotavirus-associated deaths occur in low-income countries. Currently, the available vaccines in developing countries have lower efficacy in children than those in developed countries. Due to added safety concerns and the high cost of current vaccines, there is a need to develop cost-effective next-generation vaccines with improved safety and efficacy. The reverse genetics system (RGS) is a powerful tool for investigating viral protein functions and developing novel vaccines. Recently, an entirely plasmid-based RGS has been developed for several rotaviruses, and this technological advancement has significantly facilitated novel rotavirus research. Here, we review the recently developed RGS platform and discuss its application in studying infection biology, gene reassortment, and development of vaccines against rotavirus disease.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254061PMC
http://dx.doi.org/10.1007/s00705-021-05142-7DOI Listing

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