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A Mysterious Cause of Coagulopathy With Bleeding Diathesis.
Cureus
December 2024
Department of Internal Medicine IV, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.
Vitamin K is essential to produce functional vitamin K-dependent coagulation factors (prothrombin, factors VII, IX, and X). Vitamin K antagonists inhibit the normal activation of these factors, leading to bleeding manifestations of variable severity. Long-acting vitamin K antagonists or superwarfarins were developed as rodenticides and have a significantly longer half-life and greater potency when compared to warfarin.
View Article and Find Full Text PDFAcute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report.
Front Pharmacol
November 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Brodifacoum is a highly effective rodent poison that can cause serious bleeding issues (coagulopathy), but its effects during pregnancy are not well documented.
- A case study reported a pregnant woman experiencing severe bleeding due to brodifacoum poisoning, leading to serious complications and the loss of the fetus.
- Effective management of brodifacoum poisoning is essential, with timely recognition and treatment (like vitamin K1) needed to improve outcomes for pregnant patients.
Systematic forensic identification of a homicide by brodifacoum poisoning: A case report.
J Forensic Leg Med
November 2024
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:
Brodifacoum, a long-acting anticoagulant rodenticide, exerts inhibitory effects on blood coagulation factor synthesis, leading to abnormal clotting function and potential fatality. Poisoning of accidental exposure to brodifacoum is not rare, but death from brodifacoum poisoning can be largely avoided with timely and long-term effective treatments, consequently, forensic data on fatalities due to brodifacoum poisoning may be limited. This paper presents a case of brodifacoum-induced homicide, detailing the medial records and pathological changes observed in multiple organs.
View Article and Find Full Text PDFDeploying Validated Mass Spectrometry for Frontline Detection and Treatment of Human Poisoning by Long-Acting Anticoagulant Rodenticides.
Chem Res Toxicol
November 2024
Jesse Brown VA Medical Center and Department of Anesthesiology, University of Illinois College of Medicine in Chicago, Chicago, Illinois 60612, United States.
Article Synopsis
- * LAARs can cause severe bleeding (coagulopathy) in humans if blood levels exceed 10 ng/mL, leading to numerous poisonings each year.
- * Various analytical methods, mainly using liquid chromatography-mass spectrometry (LC-MS), have been developed to quickly identify and analyze LAARs in patients experiencing severe bleeding, and these methods are evaluated for their validation and clinical utility.
Second-Generation Anticoagulant Rodenticide Toxicosis in a Wild Carnaby's Cockatoo ().
J Avian Med Surg
October 2024
School of Veterinary Medicine, Murdoch University, Murdoch, Western Australia 6151, Australia.
Article Synopsis
- * On Day 4, the bird experienced severe bleeding, nosebleeds, and anemia, leading to its euthanasia due to ongoing health decline.
- * Testing revealed high levels of anticoagulant rodenticides in its liver, marking the first recorded case of rodenticide poisoning in this wild Australian bird species.
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