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| http://dx.doi.org/10.1002/jmv.27174 | DOI Listing |
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Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury.
Clin Transl Med
January 2025
Outcomes Research Consortium®, Houston, Texas, USA.
The gastrointestinal tract can be deranged by ailments including sepsis, trauma and haemorrhage. Ischaemic injury provokes a common constellation of microscopic and macroscopic changes that, together with the paradoxical exacerbation of cellular dysfunction and death following restoration of blood flow, are collectively known as ischaemia-reperfusion injury (IRI). Although much of the gastrointestinal tract is normally hypoxemic, intestinal IRI results when there is inadequate oxygen availability due to poor supply (pathological hypoxia) or abnormal tissue oxygen use and metabolism (dysoxia).
View Article and Find Full Text PDFIdentification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics.
J Vis Exp
November 2024
Centre of Biomedical Research, SGPGIMS Campus; Academy of Scientific and Innovative Research (AcSIR);
Metabolomics is emerging as a significant approach to reflect the individual's response to pathophysiological conditions. Nuclear magnetic resonance (NMR) spectroscopy has evolved as a tool to identify metabolic dysregulations in critically ill patients afflicted with conditions like acute respiratory distress syndrome (ARDS), severe acute pancreatitis (SAP), acute kidney injury (AKI), and sepsis. The spectral data from the serum sample of the study and control group are recorded using an 800 MHz NMR spectrometer and processed using NMR processing and analysis tools.
View Article and Find Full Text PDFBackground: Neonatal birth/perinatal asphyxia is a critical condition that can adversely affect many different bodily tissues, particularly the brain; depending on duration and severity of asphyxia, leading to difficulties and lifelong disabilities. These can be avoided by early detection of the biochemical derangements and prompt intervention. Serum alpha-ketoglutarate (α-KG) and cord blood lactate have been found to be associated with birth asphyxia and may have potential to act as biomarkers for birth asphyxia.
View Article and Find Full Text PDFp63 affects distinct metabolic pathways during keratinocyte senescence, evaluated by metabolomic profile and gene expression analysis.
Cell Death Dis
November 2024
Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome, Italy.
Article Synopsis
- The study investigates the role of p63, a transcription factor, in skin aging and keratinocyte senescence, revealing that the depletion of p63 accelerates aging markers in both animal models and human cells.
- Using advanced metabolomic analysis techniques, the research identifies key metabolic pathways linked to cell senescence that change when p63 is silenced, affecting stress markers and lipid production.
- Findings suggest that p63 plays a crucial role in managing metabolic processes in keratinocytes, potentially offering insights into therapeutic strategies against skin aging and related conditions.
Rodent Model of Cardiopulmonary Bypass Demonstrates Systemic Inflammation and Neuromarker Changes.
J Surg Res
November 2024
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia. Electronic address:
Introduction: The physiologic derangements imposed by cardiopulmonary bypass (CPB) can result in complications such as postoperative delirium. We aim to validate a rodent survival model of CPB demonstrating a systemic inflammatory response and hypothesize that this contributes to post-CPB delirium.
Methods: Adult Sprague-Dawley rats were randomized to three groups: 1) Sham peripheral surgical cannulation, 2) CPB followed by acute phase harvest, or 3) CPB followed by 24-h survival.
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