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Paroxysmal sympathetic hyperactivity caused by neurosyphilis.
BMJ Neurol Open
October 2024
Department of Neurology, Tsuchiura Kyodo General Hospital, Tsuchiura-shi, Ibaraki, Japan.
Article Synopsis
- Paroxysmal sympathetic hyperactivity (PSH) is a condition linked to autonomic nervous system dysfunction, often seen in severe brain injuries, but non-traumatic causes like infections can also trigger it.
- A case study discusses a 30-year-old man diagnosed with neurosyphilis who experienced abnormal symptoms like seizures and agitation, leading to a PSH diagnosis after ruling out other conditions.
- Treatment with propranolol, gabapentin, and clonidine successfully managed his PSH symptoms, highlighting the importance of recognizing and addressing PSH early in cases of central nervous system infections.
Pediatric oral extemporaneous preparations and practices: International Pharmaceutical Federation (FIP) global study.
Eur J Pharm Biopharm
November 2024
International Pharmaceutical Federation (FIP), The Hague, Netherlands; St. Louis College of Pharmacy, University of Health Sciences and Pharmacy in St. Louis, MO, USA.
This publication is the first to report current, global, pediatric oral extemporaneous compounding practices. Complete survey responses were received from 479 participants actively involved in compounding across all the World Health Organization (WHO) regions. The survey addressed oral formulation of extemporaneous liquids, including the use of commercial or in-house vehicles, flavoring excipients, source of formulation recipes, and beyond use dates (BUDs).
View Article and Find Full Text PDFEffectiveness and Safety of Intravenous Medications for the Management of Acute Disturbance (Agitation and Other Escalating Behaviors): A Systematic Review of Prospective Interventional Studies.
J Acad Consult Liaison Psychiatry
June 2024
Neuropsychiatry Research and Education Group, Institute of Psychiatry, Psychology, and Neuroscience, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom.
Acute disturbance is a broad term referring to escalating behaviors secondary to a change in mental state, such as agitation, aggression, and violence. Available management options include de-escalation techniques and rapid tranquilization, mostly via parenteral formulations of medication. While the intramuscular route has been extensively studied in a range of clinical settings, the same cannot be said for intravenous (IV); this is despite potential benefits, including rapid absorption and complete bioavailability.
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