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Neoadjuvant pemigatinib as a bridge to living donor liver transplantation for intrahepatic cholangiocarcinoma with FGFR2 gene rearrangement.
Am J Transplant
November 2024
Transplant Institute, University of Rochester Medical Center, Rochester, New York, USA.
We report a case of a 55-year-old male with intrahepatic cholangiocarcinoma (iCCA) who underwent living donor liver transplantation (LDLT) after complete radiographic response on second-line pemigatinib. LDLT for iCCA is controversial, but recent reports have cited the potential benefit for patients with unresectable disease, especially those with disease stability after 6 months of systemic therapy. Concomitantly, genomic profiling has identified potentially treatable oncologic targets in iCCA.
View Article and Find Full Text PDFBiological and proteomic analysis of a new isolate of the nematophagous fungus lecanicillium sp.
BMC Microbiol
April 2023
Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Background: In our continuing search for biologically active natural enemies from North of Africa with special reference to Tunisian fungi, our teamwork screened fungi from different ecological habitats in Tunisia. Our previous study on the comparative effectiveness of filamentous fungi in the biocontrol of Meloidogyne javanica, a taxon (Lecanicillium) showed high potentiality against M. javanica.
View Article and Find Full Text PDFThe High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant.
Ann Surg
November 2023
Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, Rochester, NY.
Article Synopsis
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Comparative Effectiveness of Filamentous Fungi in Biocontrol of and Activated Defense Mechanisms on Tomato.
J Fungi (Basel)
December 2022
Department of Botany and Microbiology, Faculty of Science, University of Suez Canal, Ismailia 41522, Egypt.
The nematicidal potential of five filamentous fungi as biological control agents (BCAs) against the root-knot nematode (RKN), Meloidogyne javanica, infecting tomato was assessed in vitro and in pot experiments. The five promising native taxa, namely Trichoderma longibrachiatum, T. harzainum, T.
View Article and Find Full Text PDFBackground & Aims: According to pivotal clinical trials, cure rates for sofosbuvir-based antiviral therapy exceed 96%. Treatment failure is usually assumed to be because of virological resistance-associated substitutions or clinical risk factors, yet the role of patient-specific genetic factors has not been well explored. We determined if patient-specific genetic factors help predict patients likely to fail sofosbuvir treatment in real-world treatment situations.
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