Acylsilane represents a valuable synthon in synthetic chemistry. We report on ruthenium(ii)-catalyzed ortho-C-H amination of aroylsilanes to provide facile access to synthetically useful imidobenzoylsilanes and tosyl-amidobenzoylsilanes. The protocols, with broad substrate scope and excellent functional group tolerance, are enabled with the weak chelation-assistance of acylsilane via C-H cyclometallation.
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Ruthenium-catalyzed C-H amination of aroylsilanes.
Org Biomol Chem
July 2021
College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China. and Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.
Acylsilane represents a valuable synthon in synthetic chemistry. We report on ruthenium(ii)-catalyzed ortho-C-H amination of aroylsilanes to provide facile access to synthetically useful imidobenzoylsilanes and tosyl-amidobenzoylsilanes. The protocols, with broad substrate scope and excellent functional group tolerance, are enabled with the weak chelation-assistance of acylsilane via C-H cyclometallation.
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