AI Article Synopsis
- The study examined the transcriptional start sites (TSSs) of two cow sub-species, Bos taurus taurus and Bos taurus indicus, that split roughly 500,000 years ago, revealing differences in TSS usage.
- Significant changes in TSS distribution and shifts in allele frequency of 472 SNPs in certain TSS clusters were noted, suggesting these may have undergone evolutionary selection.
- Bos indicus showed higher TSS expression for heat shock protein genes in spleen and muscle, potentially indicating its adaptation to tropical environments compared to Bos taurus.
Article Abstract
To further the understanding of the evolution of transcriptional regulation, we profiled genome-wide transcriptional start sites (TSSs) in two sub-species, Bos taurus taurus and Bos taurus indicus, that diverged approximately 500,000 years ago. Evolutionary and developmental-stage differences in TSSs were detected across the sub-species, including translocation of dominant TSS and changes in TSS distribution. The 16% of all SNPs located in significant differentially used TSS clusters across sub-species had significant shifts in allele frequency (472 SNPs), indicating they may have been subject to selection. In spleen and muscle, a higher relative TSS expression was observed in Bos indicus than Bos taurus for all heat shock protein genes, which may be responsible for the tropical adaptation of Bos indicus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249380 | PMC |
| http://dx.doi.org/10.1038/s42003-021-02340-6 | DOI Listing |
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