AI Article Synopsis
- - Most meningiomas are slow-growing tumors from arachnoid cap cells, typically treatable through surgery or radiation, but aggressive cases often recur and lack established alternative treatments.
- - Identifying the risk of recurrence is crucial, with several clinical and molecular markers being used, while the invasive growth of tumor cells into CNS tissue is linked to higher recurrence rates and was included in the WHO classification of tumors.
- - Recent research confirms the prognostic significance of CNS invasion in meningiomas, despite earlier doubts, and highlights the inconsistencies in histopathological evaluations and imaging methods, indicating a need for improved assessments in future classifications.
Article Abstract
Most meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment of the risk of recurrence is therefore of utmost importance and several prognostic clinical and molecular markers have been established. Additionally, the identification of invasive growth of meningioma cells into CNS tissue was demonstrated to lead to a higher risk of recurrence and was therefore integrated into the WHO classification of CNS tumors. However, the evidence for its prognostic impact has been questioned in subsequent studies and its exclusion from the next WHO classification proposed. We were recently able to show the prognostic impact of CNS invasion in a large comprehensive retrospective meningioma cohort including other established prognostic factors. In this review we discuss the growing experiences that have been gained on this matter, with a focus on the currently nonuniform histopathological assessment, imaging characteristics and intraoperative sampling as well as the overall outlook on the future role of this potential prognostic factor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267840 | PMC |
| http://dx.doi.org/10.3390/cancers13133259 | DOI Listing |
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