Known as a key effector in breast cancer (BC) progression, calcium (Ca) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca channels are the main actors among Ca transporters that control the intracellular Ca concentration in cells. It is well known that the basal Ca concentration is regulated by both store-dependent and independent Ca channels in BC development and progression. However, most of the literature has reported the role of store-dependent Ca entry, and only a few studies are focusing on store-independent Ca entry (SICE). In this review, we aim to summarize all findings on SICE in the BC progression field.
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| http://dx.doi.org/10.3390/genes12070994 | DOI Listing |
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