Cancer is a major global public health problem and conventional chemotherapy has several adverse effects and deficiencies. As a valuable option for chemotherapy, nanomedicine requires novel agents to increase the effects of antineoplastic drugs in multiple cancer models. Since its discovery, carbon nanotubes (CNTs) are intensively investigated for their use as carriers in drug delivery applications. This study shows the development of a nanovector generated with commercial carbon nanotubes (cCNTs) that were oxidized (oxCNTs) and chemically functionalized with hyaluronic acid (HA) and loaded with carboplatin (CPT). The nanovector, oxCNTs-HA-CPT, was used as a treatment against HeLa and MDA-MB-231 human tumor cell lines. The potential antineoplastic impact of the fabricated nanovector was evaluated in human cervical adenocarcinoma (HeLa) and mammary adenocarcinoma (MDA-MB-231). The oxCNTs-HA-CPT nanovector demonstrate to have a specific antitumor effect in vitro. The functionalization with HA allows that nanovector bio-directed towards tumor cells, while the toxicity effect is attributed mainly to CPT in a dose-dependent manner.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269704 | PMC |
| http://dx.doi.org/10.3390/ma14133622 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Emerging trends and innovations in polysaccharide-derived EMI shielding materials: A comprehensive review of bibliometric and performance analysis.
Int J Biol Macromol
January 2025
Department of Physics, Hasanuddin University, Makassar 90245, Indonesia. Electronic address:
The increasing reliance on electronic devices has created a pressing demand for high-performance and sustainable electromagnetic interference shielding materials. While conventional materials, such as metals and carbon-based composites, offer excellent shielding capabilities, they are hindered by high costs, environmental concerns, and limitations in scalability. Polysaccharide-based materials, including cellulose, chitosan, and alginate, represent a promising alternative due to their biodegradability, renewability, and versatility.
View Article and Find Full Text PDFLondon dispersion forces and steric effects within nanocomposites tune interaction energies and chain conformation.
Commun Chem
January 2025
Institute of Physics, Albert-Ludwig-University of Freiburg, Freiburg, Germany.
The interplay between attractive London dispersion forces and steric effects due to repulsive forces resulting from the Pauli principle often determines the geometry and stability of nanostructures. Aromatic polyimides (PI) and carbon nanotubes (CNT) were chosen as building blocks as two components in the hetero delocalized electron nanostructures. Two PIs, having the same diamine part and different linkage substituents between two phenyl rings of dianhydride part, one linked with ether bond (C-O-C) (OPI), the other with C-(CF3)2 (FPI), were investigated.
View Article and Find Full Text PDFPotential of carbon micro/nanofibers derived from lignocellulose biomass valorisation for CO adsorption: A review on decarbonization biotechnology for climate change solutions.
Int J Biol Macromol
January 2025
Desalination Technology Institute, King Abdulaziz City for Science and Technology, Riyadh 12354, Saudi Arabia.
Biomass, as a source of lignocellulose, can be valorized into carbon micro/nanofibers for adsorbing greenhouse gas (GHGs) emissions, especially CO. This article is derived from systematic evidence evaluation of published studies, presenting new, innovative, and systemic approaches to lignocellulose-based carbon micro/nanofiber studies. The review covers a general overview of carbon micro/nanofiber studies, mapping chronicles of the studies, carbon micro/nanofiber types for CO uptake, carbon micro/nanofibers fabrication and characterization, obtained carbonaceous material activation and performances, regulatory frameworks, and sustainability.
View Article and Find Full Text PDFElectrochemical Synthesis of Polyaniline@Nano Zinc Oxide/Modified Multiwalled Carbon Nanotubes Nanocomposite Coating for Solid Phase Microextraction of Some Polycyclic Aromatic Hydrocarbons in Coffee and Grilled Meat.
J Sep Sci
January 2025
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic compounds resulting from incomplete burning of organic materials. This work describes the successful layer-by-layer fabrication of a novel zinc oxide nanocomposite made of zinc oxide nanoparticles, aniline, sodium dodecyl sulfate, and modified multi-walled carbon nanotubes on a stainless steel wire by electrodeposition. The coating and extraction conditions were screened, optimized, and validated using factorial design and central composite design, respectively.
View Article and Find Full Text PDFAdvances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment.
Pharmaceutics
January 2025
Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-8-8349, Iran.
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body's organs, tissues, and cells that can be selectively transported to specific regions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!