AI Article Synopsis
- The regeneration of soft tissues is crucial, and hydrogels made from materials like chitosan are promising due to their biocompatibility and biodegradability.
- Key processing factors like pH, gelation temperature, and biopolymer concentration significantly affect hydrogel formation, with pH being essential and a low gelation temperature enhancing mechanical properties.
- The research identifies a saturation point of chitosan (1.5 wt.%), beyond which no further improvement in hydrogel properties occurs, highlighting the potential for high-thermal-resistance applications.
Article Abstract
The regeneration of soft tissues that connect, support or surround other tissues is of great interest. In this sense, hydrogels have great potential as scaffolds for their regeneration. Among the different raw materials, chitosan stands out for being highly biocompatible, which, together with its biodegradability and structure, makes it a great alternative for the manufacture of hydrogels. Therefore, the aim of this work was to develop and characterize chitosan hydrogels. To this end, the most important parameters of their processing, i.e., agitation time, pH, gelation temperature and concentration of the biopolymer used were rheologically evaluated. The results show that the agitation time does not have a significant influence on hydrogels, whereas a change in pH (from 3.2 to 7) is a key factor for their formation. Furthermore, a low gelation temperature (4 °C) favors the formation of the hydrogel, showing better mechanical properties. Finally, there is a percentage of biopolymer saturation, from which the properties of the hydrogels are not further improved (1.5 wt.%). This work addresses the development of hydrogels with high thermal resistance, which allows their use as scaffolds without damaging their mechanical properties.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271898 | PMC |
| http://dx.doi.org/10.3390/polym13132189 | DOI Listing |
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