Furanocoumarins from with Amebicide Activity.

(protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of (Rutaceae) against . The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of afforded the furocoumarins rutamarin () and chalepin (), which showed high antiprotozoal activity on trophozoites employing in vitro tests (IC values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.