Metabolic activation of procarcinogenic 2-acetyl-amino-fluorene, benzo(a)pyrene, aflatoxin B1 and N-nitrosodimethylamine by various tissues of embryonal and newborn rats was studied with the Salmonella/microsome assay. Bioactivation by fetal tissues was shown to be significantly lower than with newborn rat tissues. When aroclor was given to pregnant females a decrease in metabolic activation was observed. This phenomenon was interpreted as a paradoxical effect. Treatment with aroclor of newborns led to a significant increase in biotransformation of all the compounds tested in the liver and after benzo(a)pyrene--in the kidney, and N-nitrosodimethylamine--in the lung.
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