[Impairment of lipid peroxidation control in patients with dust-induced lung diseases].

Content of lipid peroxides was increased in blood plasma of patients with dust-dependent diseases of lungs (fibrinogenous dust--pneumoconiosis, dust bronchitis; carcinogenous dust--dust bronchitis), whereas the tocopherol level was similar to normal values in pneumoconiosis and elevated in dust bronchitis. The increase in tocopherol content might be considered as a compensatory mechanism in response to augmented lipid peroxidation. At the same time, this compensation was not sufficiently effective, as a result of which the antioxidant activity was relatively decreased in blood plasma as well as the antioxidant control was impaired in tissues and accompanied by intensification of the free radical reactions.