The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin-Kexin Type 7 () Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides.

Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Previous reports, including genome-wide associations studies (GWAS), have shown that some genetic variants of the proprotein convertase subtilisin-kexin type 7 gene are associated with plasma lipid levels. In the present study, we evaluated whether gene polymorphisms are significantly associated with the plasma lipid profile and ACS. Three gene polymorphisms (rs508487 /, rs236911 / and rs236918 /) were determined using TaqMan genotyping assays in a group of 603 ACS patients and 622 healthy controls. The plasma lipid profile was determined in the study groups by enzymatic/colorimetric assays. Under the recessive model, the rs236918 allele was associated with a high risk of ACS (OR = 2.11, = 0.039). In the same way, under the recessive and additive models, the rs236911 allele was associated with a high risk of ACS (OR = 1.95, = 0.037, and OR = 1.28, = 0.037, respectively). In addition, under the co-dominant model, the rs508487 allele was associated with a higher risk of ACS (OR = 1.78, = 0.010). The and haplotypes were associated with a high risk of ACS (OR = 1.21, = 0.047, and OR = 1.80, = 0.001, respectively). The rs236911 and rs236918 genotypes were associated with lower high-density lipoproteins-cholesterol (HDL-C) plasma concentrations, whereas the rs236911 genotype was associated with a higher concentration of triglycerides, as demonstrated in the control individuals who were not receiving antidyslipidemic drugs. Our data suggest that the rs508487 /, rs236911 / and rs236918 / polymorphisms are associated with the risk of developing ACS, and with plasma concentrations of HDL-C and triglycerides.