Asperflaloids A and B from DZ-3, an Endophytic Fungus of Oliver.

The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Oliver and identified as . Two new alkaloids, named asperflaloids A and B ( and ), together with 10 known compounds (-) were obtained from the EtOAc extract of the strain. Interestingly, the alkaloids - with different frameworks are characterized by the presence of the same anthranilic acid residue. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of asperflaloids A and B was resolved by quantum chemistry calculation. All compounds were screened for their inhibitions against α-glucosidase and the antioxidant capacities. The results were that compound had an IC value of 750.8 μM toward α-glucosidase, and the phenol compounds and exhibited potent antioxidant capacities with IC values 14.4 and 27.1 μM respectively.