Synthesis of Hafnium(IV) Polyaminoacetates.

The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy ,,','-tetraacetic acid (dpta), and -(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na[Hf(NTA)]·3HO (), Na[HfDTPA]·3HO (), [HfCDTA(HO)] (), and Na[Hf(dpta)]·7.5HO·0.5CHOH () have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(HO)] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.