Performance enhancement and injury prevention are often perceived as opposite sides of a coin, where focusing on improvements of one leads to detriment of the other. In this study, we used physics-based simulations with novel optimization methods to find participant-specific, whole-body mechanics of volleyball spiking that enhances performance (the peak height of the hitting hand and its forward velocity) while minimizing injury risk. For the volleyball spiking motion, the shoulder is the most common injury site because of the high mechanical loads that are most pronounced during the follow-through phase of the movement. We analyzed 104 and 209 spiking trials across 13 participants for the power and follow-through phases, respectively. During the power phase, simulations increased ( < 0.025) the peak height of the hitting wrist by 1% and increased ( < 0.025) the forward wrist velocity by 25%, without increasing peak shoulder joint torques, by increasing the lower-limb forward swing (i.e., hip flexion, knee extension). During the follow-through phase, simulations decreased ( < 0.025) peak shoulder joint torques by 75% elicited by synergistic rotation of the trunk along the pathway of the hitting arm. Our results show that performance enhancement and injury prevention are not mutually exclusive and may both be improved simultaneously, potentially leading to better-performing and injury-free athletes.
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http://dx.doi.org/10.3390/life11070598 | DOI Listing |
Biochem Genet
December 2024
Department of Obstetrics and Gynecology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), No.216, Guanshan Avenue, Hongshan District, Wuhan, 430074, Hubei, China.
Cisplatin, a platinum-based chemotherapeutic agent, can be used to treat cervical cancer (CC), but cisplatin resistance is increased during the cisplatin treatment. Long non-coding RNA PGM5-AS1 reportedly participates in CC tumorigenesis; however, its role in CC patients with cisplatin resistance has not been revealed. The present aimed to examine the role of PGM5-AS1 in modulating cisplatin resistance in CC.
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December 2024
Department of Biotechnology, Faculty of Agro-industry, Kasetsart University, Bangkok, 10900, Thailand.
Tilapia lake virus (TiLV) disease is highly contagious and causes substantial mortality in tilapia. Currently, no effective treatments or commercial vaccines are available to prevent TiLV infection. In this study, TiLV segment 4 (S4) was cloned into the pET28a(+)vector and transformed into Escherichia coli BL21(DE3).
View Article and Find Full Text PDFFatigue cracking of rib-to-deck conventional single-sided welded joints is a prevalent issue in orthotropic steel decks (OSDs), significantly impacting their structural integrity and durability. Rib-to-deck innovative double-sided welded joints have the potential to enhance the fatigue resistance of OSD. However, Welding Residual Stresses (WRS) significantly influence the fatigue life of these joints, mandating its consideration in fatigue assessments.
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December 2024
Interventional Oncology, Johnson & Johnson Enterprise Innovation, Inc, 10th Floor 255 Main St, 02142, Cambridge, Boston, MA, USA.
The introduction of anti-PD-1/PD-L1 therapies revolutionized treatment for advanced non-small cell lung cancer (NSCLC), yet response rates remain modest, underscoring the need for predictive biomarkers. While a T cell inflamed gene expression profile (GEP) has predicted anti-PD-1 response in various cancers, it failed in a large NSCLC cohort from the Stand Up To Cancer-Mark (SU2C-MARK) Foundation. Re-analysis revealed that while the T cell inflamed GEP alone was not predictive, its performance improved significantly when combined with gene signatures of myeloid cell markers.
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December 2024
College of Advanced Manufacturing Innovation, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Vector-borne diseases pose a major worldwide health concern, impacting more than 1 billion people globally. Among various blood-feeding arthropods, mosquitoes stand out as the primary carriers of diseases significant in both medical and veterinary fields. Hence, comprehending their distinct role fulfilled by different mosquito types is crucial for efficiently addressing and enhancing control measures against mosquito-transmitted diseases.
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