AI Article Synopsis
- The focus on developing user-friendly, portable, and low-cost healthcare devices for COVID-19 screening has intensified since the pandemic began, alongside existing diagnostic methods like RT-PCR and CT scans.
- Researchers are exploring additional solutions for COVID-19 diagnosis by identifying clinical biomarkers such as pro-inflammatory cytokines and acute phase proteins, which can provide insights into the disease's severity and aid in drug and vaccine development.
- This review highlights the potential use of these biomarkers in electrical biosensing platforms for COVID-19, discussing the current state of electrochemical and electronic biosensors and their role in enhancing diagnosis and prognosis for infected patients.
Article Abstract
The race towards the development of user-friendly, portable, fast-detection, and low-cost devices for healthcare systems has become the focus of effective screening efforts since the pandemic attack in December 2019, which is known as the coronavirus disease 2019 (COVID-19) pandemic. Currently existing techniques such as RT-PCR, antigen-antibody-based detection, and CT scans are prompt solutions for diagnosing infected patients. However, the limitations of currently available indicators have enticed researchers to search for adjunct or additional solutions for COVID-19 diagnosis. Meanwhile, identifying biomarkers or indicators is necessary for understanding the severity of the disease and aids in developing efficient drugs and vaccines. Therefore, clinical studies on infected patients revealed that infection-mediated clinical biomarkers, especially pro-inflammatory cytokines and acute phase proteins, are highly associated with COVID-19. These biomarkers are undermined or overlooked in the context of diagnosis and prognosis evaluation of infected patients. Hence, this review discusses the potential implementation of these biomarkers for COVID-19 electrical biosensing platforms. The secretion range for each biomarker is reviewed based on clinical studies. Currently available electrical biosensors comprising electrochemical and electronic biosensors associated with these biomarkers are discussed, and insights into the use of infection-mediated clinical biomarkers as prognostic and adjunct diagnostic indicators in developing an electrical-based COVID-19 biosensor are provided.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198817 | PMC |
| http://dx.doi.org/10.3390/s21113829 | DOI Listing |
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