A new two-column Ac/Bi generator was developed specifically for using Ac containing an impurity of long lived Ac. The parent Ac was retained on the first Actinide Resin column, while Bi was accumulated on the second column filled with AG MP-50 resin via continuous elution and decay of intermediate Fr. The Bi accumulation was realized in circulation mode which allowed a compact generator design. It was demonstrated that Bi could be quickly and effectively extracted from AG MP-50 in form of complexes with various chelating agents including DTPA and DOTA. The performance of the generator presented and a conventional single-column generator on the base of AG MP-50 was tested and both generators were loaded with Ac containing Ac impurity. The Bi generation efficiencies were comparable and greater than 70%, whereas the developed generator provided a deeper degree of purification of Bi from Ac isotopes and decay products of Ac.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234463 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics13060914 | DOI Listing |
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