Wall., commonly known as "Pangpo Tea", is traditionally used as a folk medicine and healthy tea for the treatment of liver and intestine diseases. The aim of this study was to purify the antioxidative and cytoprotective polyphenols from leaves. After fractionation with polar and nonpolar organic solvents, the fractions of aqueous ethanol extract were evaluated for their total phenolic (TPC) and flavonoid contents (TFC) and antioxidant activities (DPPH, ABTS, and FRAP assays). The -butanol fraction (BF) showed the highest TPC and TFC with the strongest antioxidant activity. The bio-guided chromatography of BF led to the purification of six flavonoids (-) and one benzoquinolethanoid (). The structures of these compounds were determined by NMR and MS techniques. Compound had the strongest antioxidant capacity, which was followed by and . The protective effect of the isolated compounds on hydrogen peroxide (HO)-induced oxidative stress in HepG2 cells revealed that the compounds and exhibited better protective effects by inhibiting ROS productions, having no significant difference with vitamin C ( > 0.05), whereas showed the best anti-apoptosis activity. The results suggest that could serve as a valuable antioxidant phytochemical source for developing functional food and health nutraceutical products.
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| http://dx.doi.org/10.3390/molecules26123690 | DOI Listing |
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