Mycosis fungoides (MF) is the most prevalent type of skin lymphoma. In its early stages, it has a favorable prognosis. However, in its late stages, it is associated with an increased risk of mortality. This systematic review aimed to identify the transcriptomic changes involved in MF pathogenesis and progression. A literature search was conducted using the database PubMed, followed by the extraction of 2245 genes which were further filtered to 150 recurrent genes that appeared in two or more publications. Categorization of these genes identified activated pathways involved in pathways such as cell cycle and proliferation, chromosomal instability, and DNA repair. We identified 15 genes implicated in MF progression, which were involved in cell proliferation, immune checkpoints, resistance to apoptosis, and immune response. In highlighting the discrepancies in the way MF transcriptomic data is obtained, further research can focus on not only unifying their approach but also focus on the 150 pertinent genes identified in this review.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229125PMC
http://dx.doi.org/10.3390/cells10061409DOI Listing

Publication Analysis

Top Keywords

systematic review
8
mycosis fungoides
8
genes identified
8
genes
5
patterns gene
4
gene expression
4
expression cutaneous
4
cutaneous t-cell
4
t-cell lymphoma
4
lymphoma systematic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!